In this episode of the podcast we are joined by Dr. Phillip Sharp, Nobel Prize Laureate and Institute Professor at MIT, who shares his story behind the groundbreaking discovery of RNA splicing. He explains how the work ethic and problem solving instinctions he built early on eventually led him to Caltech, and then MIT, where his 1977 discovery changed how we understand gene expression. Sharp discusses his journey from science into biotech entrepreneurship, co-founding both Biogen and Alnylam, and delves into his role as a pioneer of the industry. This episode offers a firsthand account of biotech’s earliest days, along with advice for founders on risk, communication strategies, and what it takes to build a successful company. Book mentioned: The Double Helix by James D. Watson
Time Stamps:
(3:10) Phillip’s background and how it shaped his character
(6:13) What first sparked his passion for science
(9:15) What inspired his PhD journey
(17:35) The discovery of restriction enzymes and DNA synthesis, concerns about DNA manipulation and how NIH guidelines came to be
(25:00) How to communicate your science and translate that knowledge for public benefit
(33:17 The discovery of RNA splicing
(48:40) The founding of Alnylam
(58:10) The creation of the biotech industry
(1:03:30) How to keep up with the latest science and important trends to watch
(1:12:55) Advice for founders looking to launch their own companies
(1:16:47) Traits to look for in a mentor and what makes a strong mentor-mentee relationship
(1:19:53) Critical pieces of company culture that drive success
(1:24:59) Quick fire questions